In my paper published in the free access journal 'Sustainability' I discuss the value of decentralized economic complexity for sustainable and inclusive change. For that purpose, I look at two innovative and resilient economic ecosystems in Switzerland The first case study looks at the economic region of Monthey. It shows how productive migrants and embedded multinational companies increase the knowledge and know-how of local small and medium-sized enterprises (SMEs). The second case study highlights the importance of the federalist system by showing how the canton of Solothurn succeeded in nurturing globally competitive export-oriented SMEs. Both case studies indicate that the global knowledge economy may not just pose a threat, but also offer great opportunities for productive regions beyond the major global high-tech clusters of economic complexity.